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. 2015 Jun 24;7(7):3380–3391. doi: 10.3390/v7072777

Figure 1.

Figure 1

Illustration of the formation and activation of the NLRP3 inflammasome. The NLRP3 monomer can be activated by its ligands and oligomerized to form a defined oligomer. The recruitment of ASC (apoptosis-associated speck-like protein containing a caspase recruitment domain) is the linkage of NLRP3 with the recruited pro-caspase-1 through PYD and CARD domains. Pro-caspase-1 autoactivates to become an active caspase-1, which then cleaves the pro-inflammatory cytokines pro-IL-1β and pro-IL-18 to produce active cytokines.