Table 2.

Results obtained from VSV-infected knockout mice and their derived cell lines.

ISG	Mechanisms	References
PKR−/− mice	Are more susceptible to VSV infection and die from acute infection of the respiratory tract.	[47]
	IFNα/β is unable to rescue PKR−/− mice from VSV infection.	[34]
PKR−/−, RNaseL−/−, Mx1−/− MEFs	IFN still inhibits VSV replication revealing the existence of other pathways.	[33]
PML−/− mice	Have an increased susceptibility to VSV compared to parental mice	[43]
p53−/− mice	Are more sensitive to VSV infection compared to parental. mice.	[36]
Ifit2 (ISG54)−/− mice	Are very vulnerable to neuropathogenesis caused by VSV infection.	[38]
Tetherin−/− mice	Intranasal infection of VSV results in lower viral titers in lungs.	[99]