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. 2015 Jul 20;7(7):4047–4074. doi: 10.3390/v7072805

Figure 5.

Figure 5

MiR-149 and miR-873 promote chromatin remodeling. The Tax protein promotes HTLV-1 gene expression by its interaction with the long terminal repeat (LTR) or U3 region of the viral promoter. To activate the transcription, Tax recruits the p300/CREB-binding protein (p300/CBP) and p300/CBP-associated factor (P/CAF), which bind two different regions of Tax, resulting in histone acetylation and chromatin remodeling. MiR-149 and miR-873 are downregulated in HTLV-1-transformed cell lines and target the chromatin remodeling factors p300 and p/CAF.