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NS5B inhibitors. (a) The three allosteric sites of NS5B are highlighted with space filling representations of inhibitors that bind in these locations. Thumb site 1 (NNI-1) in yellow, thumb site 2 (NNI-2) in green, palm sites (NNI-3/4) in purple; (b) chemical structures of NIs and NNIs that are in clinical trials or have already been approved [52,53,54,55,56,57,58,59].
