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Significantly reduced ALDH2 enzymatic activity in Aldh2E487K KI mouse hepatocytes. Primary hepatocytes from WT and Aldh2E487K KI mice were analyzed for ALDH2 activity in vitro (mean ± SEM; **P < 0.01; n = 6) (A) and for ACE clearance over a short (B) or long (C) time course (mean ± SEM; n = 3).
