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Defective alcohol metabolism in Aldh2E487K KI mice after acute ethanol challenge. Serum ACE concentrations from WT and Aldh2E487K KI mice acutely challenged with ethanol at 2 g/kg (A), 4 g/kg (B), or 8 g/kg (C) over 12 h (mean ± SEM; n = 3). Behavioral scores of mice subjected to 2 g/kg (D), 4 g/kg (E), or 8 g/kg (F) ethanol over the same time course (mean ± SEM; n = 6).
