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EGFR TKIs paradoxically activate ERK1/2 in EGFR-mutated NSCLC cells. (A–D) Western blot analysis. Exponentially growing HCC827 cells were treated with erlotinib (A and B) or lapatinib (C and D) at the indicated concentrations and collected after 1 h (A and C) and 6 h (B and D) of treatment.
