Skip to main content
. 2015 Jul 6;112(29):8953–8958. doi: 10.1073/pnas.1507606112

Fig. 3.

Fig. 3.

Activation of the Lzr gene cluster. (A) Comparison of the Lzr gene cluster with other indolotryptoline gene clusters. (B) Sequential replacement of promoters and the lzrXI pseudogene in the Lzr gene cluster and HPLC analysis of extracts from cultures of S. albus transformed with refactored gene clusters. (C) The proposed biosynthetic scheme for the lazarimides. The structures of lazarimides A (7), B (6), and C (5) were elucidated by NMR. The structure and absolute configuration of 5 were confirmed by X-ray crystallography (SI Appendix). (D) IC50 values for indolotryptolines against HCT-116 cancer cells.