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. 2015 Jul 6;112(29):E3883–E3892. doi: 10.1073/pnas.1501662112

Fig. 5.

Fig. 5.

lncRNA-CD244 regulates IFN-γ and TNF-α expression in active TB infection. (A and B) ChIP-qPCR analysis of H3K9Me1, H3K9Me2, H3K9Me3, H3K4me3, H3K27Me3, and control antibodies at the promoters of IFN-γ (A) and TNF-α (B) in CD8+ T cells transfected with indicated siRNAs. (C) Representative CBA assays of PBMCs from a patient with active TB showing that, compared with siRNA-Ctrl or transfection medium, siRNA-lncRNA-CD244 induced significant increases in concentrations of IFN-γ/TNF-α. (D and E) Pooled data showing the concentrations of IFN-γ/TNF-α upon transfection of indicated siRNAs or medium (n = 7). *P < 0.05; **P < 0.01; ***P < 0.001; NS, no statistical significance. Error bars represent SEM from three independent experiments.