Fig. 7.

Adoptive transfer of lncRNA-CD244–depressed CD8⁺ T cells to MTB-infected SCID mice reduced MTB infection and TB pathology compared with lncRNA-CD244–expressed controls. (A) Schematic diagram shows the experimental strategy of adoptive transfer of CD8⁺ T cells with inhibited lncRNA-CD244 expression, culture supernatants of indicated CD8⁺ T cells, and monocytes in MTB-infected mice. (B) Bacterial load (CFU, H37Rv) in the lungs and peripheral blood of mice indicated in A (n = 8 mice per group). (C) Representative digital camera images of lungs collected from mice receiving transfer of indicated cells with or without knock down of lncRNA-CD244. Yellow arrows mark the necrosis. (D) H&E-stained lung sections derived from two representative mice in each group of mice indicated in A. Yellow arrows mark the infiltration of red blood cells or damage of pulmonary structure. The magnification is shown at the lower right of each image. *P < 0.05. Error bars represent SEM from two independent experiments.