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Parameters of synergistic reduction of pain by combination of 4-PBA and TPPU
| at ED50 | at ED97 | |
| Combination index (CI) | 0.63* | 0.25** |
| Drug reduction index for TPPU | 4.9 fold | 218 fold |
| Drug reduction index for 4-PBA | 2.2 fold | 3.9 fold |
CI < 1 indicates synergistic interaction, **CI < 0.3 indicates strong synergistic interaction.
