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. 2015 Jul 20;112(29):8835–8842. doi: 10.1073/pnas.1502599112

Table S1.

Gene mutations found in some human cancers

Mutated genes Function Refs.
Acute myeloid leukemia
 SMC3 Structural maintenance of chromosomes 3 (14)
 SMC1A Structural maintenance of chromosomes 1A (14)
 STAG2 Stromal antigen 2 (14)
 RAD21 RAD21 homolog (14)
 FLT3 Fms-related tyrosine kinase 3 (68)
 NPM1 Nucleophosmin (nucleolar phosphoprotein B23 (68)
 DNMT3A DNA (cytosine-5-)-methyltransferase 3 alpha (68)
 IDH1 Isocitrate dehydrogenase 1 (68)
 IDH2 Isocitrate dehydrogenase 2 (68)
 TET2 Tet methylcytosine dioxygenase 2 (68)
 RUNX1 Runt-related transcription factor 1 (68)
 TP53 Tumor protein p53 (68)
 NRAS Neuroblastoma RAS viral (v-ras) oncogene homolog (68)
 CEBPA CCAAT/enhancer binding protein (68)
 WT1 Wilms tumor 1 (68)
 PTPN11 Protein tyrosine phosphatase (68)
 KIT V-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog (68)
 U2AF1 U2 small nuclear RNA auxiliary factor 1 (68)
 KRAS V-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog (68)
 SMC1A Structural maintenance of chromosomes 1A (68)
 PHF6 PHD finger protein 6 (68)
 STAG2 Stromal antigen 2 (68)
 FAM5C Family with sequence similarity 5 (68)
 EZH2 Enhancer of zeste homolog 2 (68)
 HNRNPK Heterogeneous nuclear ribonucleoprotein K (68)
Breast cancer
 TP53 Tumor protein p53 (69)
 PIK3CA Phosphatidylinositol-4 (69)
 RB1 Retinoblastoma 1 (69)
 PTEN Phosphatase and tensin homolog (69)
 MAP3K1 Mitogen-activated protein kinase kinase kinase 1 (70)
 CDKN1B Cyclin-dependent kinase inhibitor 1B (70)
 TBX3 T-box 3 (70)
 RUNX1 Runt-related transcription factor 1 (70)
 LDLRAP1 Low density lipoprotein receptor adaptor protein 1 (70)
 STMN2 Stathmin-like 2 (70)
 MYH9 Myosin (70)
 AGTR2 Angiotensin II receptor (70)
 STMN2 Stathmin-like 2 (70)
 SF3B1 Splicing factor 3b (70)
 CBFB Core-binding factor (70)
 AKT2 V-akt murine thymoma viral oncogene homolog 2 (71)
 ARID1B AT rich interactive domain 1B (SWI1-like) (71)
 CASP8 Caspase 8 (71)
 CDKN1B Cyclin-dependent kinase inhibitor 1B (71)
 MAP3K13 Mitogen-activated protein kinase kinase kinase 13 (71)
 NCOR1 Nuclear receptor corepressor 1 (71)
 SMARCD1 SWI/SNF related (71)
 GATA3 GATA binding protein 3 (12)
 MAP2K4 Mitogen-activated protein kinase kinase 4 (12)
Prostate cancer
 SPOP Speckle-type POZ protein (12)
 FOXA1 Forkhead box A1 (12)
 MED12 Mediator complex subunit 12 (12)
 CHD1 Chromodomain helicase DNA binding protein 1 (73)