Table 1.

Mutations that may contribute to the loss of differentiation into stumpy and insect forms in T. evansi and T. equiperdum by comparison with T. brucei

Gene groups (T. brucei)	Difference (T. evansi/T. equiperdum)	Refs.
Mitochondrion
Respiratory chain complexes (15 genes)	Absence of all genes/absence of 11 genes and one truncated in some isolates	(36)
Mitochondrial ribosomal genes (3 genes)	Absence of all genes/one absent and one truncated in some isolates	(36)
RNA editing guide RNA genes (>100 genes)	Absence of most genes/absence of most genes	(36)
Nucleus
Respiratory chain complexes (>50 genes)	Mutations found in at least 3 genes/mutations found in at least 1 gene	(36, 37)
Procyclin-associated genes (7 genes)	Absence of PAG3 and mutations in others/absence of PAG3 and mutations in other genes in some isolates	(38)
Proteins associated with differentiation (PADs, 8 genes)	Mutations and frame shifts in 7 genes/mutations and frame shifts in 7 genes in some isolates	(38)