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. 2015 Jul 20;112(29):8922–8928. doi: 10.1073/pnas.1505464112

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Fig. 5. — Model of clonal frequencies of germline (or somatic) stem cells in an individual. (Left) Equally competitive stem cells coexist. (Center) Supercompetitor stem cells expand at the expense of normal stem cells, but the supercompetitor stem cells + normal stem cells do not exceed the stem cell frequency for that type of stem cell. (Right) The heritable changes in a stem cell lineage allow the clone to expand dramatically and beyond the frequency limitation of the previous part. Here the stem cell resembles a cancer stem cell.