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. 2015 Jul 28;9:283. doi: 10.3389/fncel.2015.00283

FIGURE 4.

FIGURE 4

Neph2-/- mice display reduced novel object recognition but normal spatial and fear learning and memory. (A) Neph2-/- mice (8–16 weeks) show reduced novel object recognition. (n = 12 for WT, and 15 for KO, ∗p < 0.05, Student’s t-test). (B–D) Neph2-/- mice (8–16 weeks) perform normally in the learning, probe, and reversal learning phases of the Morris water maze test. The number of exact crossing over the platform (D) represents a more stringent measure of spatial memory. The swimming speed was also normal (data not shown). (n = 9 for WT and KO, ns, not significant, repeated measures ANOVA and Student’s t-test). (E) Normal contextual fear conditioning in Neph2-/- mice (8–16 weeks). (n = 9 for WT and KO, ns, not significant, Student’s t-test). (F) Normal contextual fear extinction in Neph2-/- mice. (n = 9 for WT and KO, ns, not significant, Student’s t-test).