FIGURE 5.
Neph2-/- mice display normal pattern separation. (A–E) Normal pattern separation in Neph2-/- mice (8–16 weeks), as determined by the fear conditioning test using two similar contexts. Freezing levels during stages of fear conditioning (days 1–3), introduction of a similar context (context B; ays 4–5), and discrimination learning of contexts A and B (days 6–11) are indicated. (n = 10 for WT and KO, ns, not significant, Student’s t-test and repeated measures ANOVA). (F,G) Normal pattern separation of Neph2-/- mice (8–16 weeks) in the radial arm maze working memory test, where three different arm angles (sample vs. choice) were used. (n = 21 for WT, and 13 for KO, repeated measures ANOVA).