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. 2015 Jul 28;9:283. doi: 10.3389/fncel.2015.00283

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Copyright © 2015 Choi, Han, Cutforth, Chung, Park, Lee, Kim, Kim, Choi, Shen and Kim.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Neph2^-/- mice show normal spine density and spontaneous excitatory transmission in the hippocampal DG. (A,B) Normal density of dendritic spines in Neph2^-/- DG granule cell dendrites (∼8 weeks), as measured by biocytin infusion into Neph2^-/- slices. (n = 11 cells from 5 mice for WT, and 14 cells from 5 mice for KO, ns, not significant, Student’s t-test). (C–E) Normal frequency and amplitude of mEPSCs in Neph2^-/- DG granule cells (8 weeks). (n = 16, 5 for WT, and 17, 5 for KO, ns, not significant, Student’s t-test).