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. 2015 Jul 28;5:12521. doi: 10.1038/srep12521

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Copyright © 2015, Macmillan Publishers Limited

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(A) Ratio of cytoplasmic to nuclear RNA levels indicates nuclear retention of FL-HTTQ82 RNA. Student’s t-test, n = 3 biological replicates. **P < 0.01, versus FL-HTTQ23. Levels of cytoplasmic and nuclear FL-HTT RNA showed the regulatory effect of MBNL1 variant overexpression (A) and endogenous MBNL1 knock-down (B) on nuclear retention of FL-HTTQ82 RNA. Student’s t-test or one-way ANOVA, n = 3 biological replicates. *P < 0.05, **P < 0.01, ***P < 0.001, ns = no significance, versus GFP group or control siRNA group. No effect of MBNL1 overexpression (C) or endogenous MBNL1 knock-down (D) on levels of total FL-HTT RNA was observed. Student’s t-test, n = 3 biological replicates. ns = no significance, versus GFP group or control siRNA group.