Table 2.

Study characteristics of studies describing consecutive patients suspected of CVT

	Study design	All/isolated headache patients	D-dimer test	Cut-off value	Imaging	Missing information
Tardy et al. [16]	Prospective	52/23	ELISA Vidas assay	>0.5 μg/ml	MRA	None missing
Kosinski, et al. [14]	Prospective	343/291	2nd generation latexagglutination	>0.5 μg/ml	MRA or CTV	None missing
Meng, et al. [17]	Prospective	233/173	Immuno- turbidimetric assay	>0.5	MRI/MRV	None missing
Tanislav et al. [23]	Retrospective	239/X	Turbidimetric	>0.19 μg/ml	CTV or MRV	Isolated headache unclear
Ghaffarpour et al. [24]	Prospective	104/X	Conventional ELISA	>0.5 μg/ml		Isolated headache unclear
Gouda, Sabry [21]	Prospective	104/X	2nd generation latexagglutination	>0.5 μg/ml	TOF MRA	isolated headache unclear in non CVT group
Lalive, et al. [20]	Prospective	54/X	ELISA Vidas assay	>0.5 μg/ml	MRA	Isolated headache unclear in non CVT group
Cucchiara, et al. [22]	Prospective	31/X	ELISA Vidas assay	>0.5 μg/ml	MRV	Isolated headache unclear in non CVT group

MRA MR angiography, MRV MR venography, CTV CT venography, TOF time of flight, CVT cerebral venous thrombosis