Figure 1. A genetic screen for modifiers of Notch-induced proliferation in the Drosophila eye.
(A) Examples of screen phenotypes. E1>Nact results in larger eyes (second panel), compared to wild-type (E1Gal4 alone) controls (top panel). Examples of three enhancers, c01597 (fng), c03191 (Mef2), and d07478 (Lck), and one suppressor, d09869 (Cad99C), are shown. (B) Analysis of enrichment of GO terms among the 360 Drosophila genes identified in the screen. Only enriched terms with corrected p-value < 0.05 (using Benjamini–Hochberg correction) are shown. For numerical p-values, please see Supplementary file 2. (C) Gene association analysis among cell cycle genes identified in the genetic screen. Genetic interactions, physical interactions, predicted interactions, and shared protein domains were mapped using GeneMania (www.genemania.org) between the 31 cell cycle genes from our screen (black circles) and Notch (yellow). Genes labeled with grey circles are part of the network but were not identified in our screen.