Figure 8. Model of convergence and divergence of the Notch/Mef2/JNK and Notch/Src/JNK signaling axes.
N/Mef2 and N/Src synergies converge on JNK, through eiger-dependent and eiger-independent means respectively. Some downstream processes are common to both synergies, such as MMP1 activation and bypass of G1 phase of the cell cycle via dap downregulation. Other downstream outputs, such as apoptosis, level of JAK/STAT activation, and regulation of Notch target genes, diverge between N/Src and N/Mef2 synergy.