Figure 3.
Effects of Nox4/p22-phox expression on endogenous levels of Nox4 mRNA. Adventitial myofibroblasts were transfected with either plasmids expressing human Nox4 and p22- phox or an empty vector control. Then they were stimulated with either Ang II (100 nmol/L) or vehicle, and mRNA levels for endogenous Nox4 and 18sRNA were determined using real-time PCR with rat-specific primers and probes. Data are expressed as the ratio of Nox4 mRNA vs 18sRNA and were plotted as a percentage of empty vector plus vehicle control on the day of assay±SEM. * P<0.05; n=6.