Figure 5.
Effects of h-Nox4/p22 overexpression on Ang-II–induced migration of adventitial myofibroblasts. Adventitial myofibroblasts transfected with an empty vector control (black bars) or plasmids expressing Nox4 and p22-phox (gray bars) were treated with vehicle or Ang II in the presence or absence of catalase, and migration was measured after 6 hours. Data are expressed as the percentage increase in migration induced by Ang II (100 nmol/L) vs vehicle control. *P<0.01 vs empty vector control; n=15.