Table 1.
Demographics and characteristics of patients with diarrhea with or without adenovirus detected in stool
| Characteristic | All patients (n=71) | Patients AdV stool (n=39) | Patients No AdV stool (n=32) | P |
|---|---|---|---|---|
| Age (years) | ||||
| Mean (SD) | 9.6 (6.1) | 8.3 (5.10) | 11.3 (6.9) | 0.07 |
| Median (Range) | 9.0 (1.0–24) | 8.0 (1.5 – 18.0) | 12.0 (1.0–24.0) | |
| Male sex | 36 (51) | 24 (62) | 12 (38) | 0.06 |
| Diagnosis heme malignancy | 61 (86) | 34 (87) | 27 (84) | 0.74 |
| Remission prior to transplant | 39 (55) | 23 (59) | 16 (50) | 0.48 |
| Total body irradiation | 14 (20) | 7 (18) | 7 (22) | 0.77 |
| Reduced-intensity conditioning | 29 (41) | 20 (51) | 9 (28) | 0.06 |
| T-cell depletion | 31 (44) | 14 (36) | 17 (53) | 0.16 |
| Donor Classification | 0.20 | |||
| Matched-related donor | 7 (10) | 5 (13) | 2 (6) | |
| Matched-unrelated donor | 30 (42) | 19 (49) | 11 (35) | |
| Haplo-identical donor | 32 (45) | 15 (38) | 17 (53) | |
| Cord | 2 (3) | 0 (0) | 2 (6) | |
| Product Type | 0.08 | |||
| Bone marrow | 37 (52) | 24 (62) | 13 (41) | |
| Peripheral blood | 32 (45) | 15 (38) | 17 (53) | |
| Cord | 2 (3) | 0 (0) | 2 (6) | |
| Viral prophylaxis | 0.85 | |||
| ACV | 59 (83) | 33 (85) | 26 (81) | |
| Inpatient status | 51 (72) | 30 (77) | 21 (66) | 0.42 |
| GVHD (Grade II–IV) | 25 (35) | 14 (36) | 11 (34) | 1.00 |
| Nutrition | 0.04 | |||
| Parenteral+ enteral | 47 (66) | 30 (77) | 17 (53) | |
| Enteral | 24 (34) | 9 (23) | 15 (47) | |
| Ultrasound evidence of colitis | 14 (20) | 11 (28) | 3 (9) | 0.07 |
| Vomiting | 16 (23) | 16 (41) | 0 (0) | <0.001 |
| Blood in stool | 5 (7) | 2 (5) | 3 (9) | 0.65 |
| Use of steroids at time of infection | 22 (31) | 14 (36) | 8 (25) | 0.44 |
| ALC (cells/μL) | 0.85 | |||
| Mean (SD) | 435.9 (870) | 492.7 (1075) | 366 (530) | |
| Median (range) | 84 (0.0–5293) | 76 (0.0–5293) | 119 (0.0–2200) | |
| ANC (cells/μL) | 0.55 | |||
| Mean (SD) | 1844 (2385) | 1703 (2387) | 2016 (2410) | |
| Median (range) | 1100(0–11600) | 1100 (0–11600) | 1250 (0–9400) | |
Data are number (%) unless otherwise indicated. Abbreviations : AdV, adenovirus; ACV, acyclovir; GVHD, graft-versus-host disease; ALC, absolute lymphocyte count; ANC, absolute neutrophil count; SD, standard deviation.