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. 2015 Jul 28;5:12667. doi: 10.1038/srep12667

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(A) Classical LFS (1 Hz for 15 min) failed to induce LTD in non-stressed control rats. (B) Stress enabled LFS to induce a stable LTD in saline-treated rats. (C) Fluoxetine (10 mg/kg, i.p.) itself had no effect on LTD induction in non-stressed rats. (D) Fluoxetine injection 30 min before stress fully prevented stress-facilitated hippocampal LTD. (E) The bar graph summarized the average percentage change of fEPSP amplitude before and 55 min after HFS. Representative traces are shown on the right. **p < 0.01, post hoc Turkey’s test after ANOVA (F_{(3, 20)} = 7.705; p = 0.001).