Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2015 Jul 23;9:3837–3851. doi: 10.2147/DDDT.S85357

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© 2015 Liu et al. This work is published by Dove Medical Press Limited, and licensed under Creative Commons Attribution – Non Commercial (unported, v3.0) License

The full terms of the License are available at http://creativecommons.org/licenses/by-nc/3.0/. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed.

PMC Copyright notice

Mutations in EGFR kinase domain and topological distribution of the binding pockets in the catalytic cleft.

Notes: (A) TKI-sensitive and resistant mutations. (B) Subregions of binding pockets of EGFR with DFG-in conformation and DFG-out conformation. A, adenine binding pocket; R, ribose pocket; P, phosphate pocket; E0, entrance pocket 0; E1, entrance pocket 1; E2, entrance pocket 2; K, small region in the deep front pocket; BP-I, back pocket I; BP-II, back pocket II; BP-III, back pocket III; BP-IV, back pocket IV. (C) Mapping the ligands (Erlotinib in 1M17 EGFR protein and lapatinib in 1XKK EGFR protein) into subregions of the binding pockets in the 3D view.

Abbreviations: EGFR, epidermal growth factor receptor; TKI, tyrosine kinase inhibitor; BP, back pocket; LREA, Leu-Arg-Glu-Ala; NPG, Asn-Pro-Gly; SVQ, Ser-Val-Gln; DFG, Asp-Phe-Gly.