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. 2015 Jul 23;9:3867–3876. doi: 10.2147/DDDT.S75702

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© 2015 Huang et al. This work is published by Dove Medical Press Limited, and licensed under Creative Commons Attribution – Non Commercial (unported, v3.0) License

The full terms of the License are available at http://creativecommons.org/licenses/by-nc/3.0/. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed.

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Contour plots and one factor plot showing the effect of independent variables on skin permeation of DF.

Notes: (A) Combined effect of sodium lauryl sulfate (SLS) and time of ultrasound application on skin permeation-enhancement effect of diclofenac (DF) through the skin. Both factors showed linear enhancement in permeation. (B) Effect of single-factor SLS concentration on skin permeation of DF. The effect was statistically significant (P=0.0134) on DF permeation through the skin. (C) Combined effect of ultrasonic application time and probe-to-skin distance on skin permeation-enhancement effect of DF through the skin. (D) Effect of single-factor ultrasound-application time on skin permeation of DF. The effect was statistically significant (P=0.0077) on DF permeation through the skin.