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. 2015 Jul 29;13:247. doi: 10.1186/s12967-015-0613-y

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© Guo et al. 2015

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 4 — Expression profiling of immune-associated genes in tumors from treated mice. a Mice (6 mice per group) inoculated i.p. with 1 × 10⁶ ID8 cells 10 day earlier were treated as described in Fig. 1a. Seven days after treatment commencement, tumors were excised and their RNA were extracted for the analysis of immune-associated gene expression by quantitative RT-PCR. a The expression of Th1-related molecules CXCR3, CXCL9, CXCL10, T-bet, IL-12p40 and IFN-γ. b, c The expression of genes relating with TAM/MDSC and Treg recruitment/accumuation and function, including CCL2, CXCL12, CD14, M-CSFR, Arginase-1, iNOS, IL-1β, IL-6, IL-10, TGF-β, VEGF and FoxP3. *P < 0.05, **P < 0.01, ***P < 0.001.