Table 2.
Predictors of recurrence after resection of intrahepatic cholangiocarcinoma (n = 153)
| Characteristic | Univariate | Multivariate | ||
|---|---|---|---|---|
| HR (95 % CI) | p value | HR (95 % CI) | p value | |
| Sex | 1.046 (0.688–1.589) | 0.835 | ||
| Age | 1.011 (0.988–1.034) | 0.360 | ||
| PT–INR | 7.894 (1.041–59.841) | 0.046 | ||
| Type of resection | 0.483 | |||
| Wedge resection | 0.917 (0.223–9.767) | 0.904 | ||
| Segmentectomy | 1.264 (0.601–2.661) | 0.537 | ||
| Multiple segmentectomy | 0.729 (0.399–1.335) | 0.306 | ||
| Hemihepatectomy | 1 | |||
| Extended hemihepatectomy | 1.419 (0.799–2.518) | 0.232 | ||
| Tumor subtype | 0.386 (0.221–0.676) | 0.001 | ||
| Histology | 0.394 (0.144–1.075) | 0.069 | ||
| Tumor size ≥4.0 cm | 2.932 (1.830–4.696) | <0.001 | 2.522 (1.556–4.088) | <0.001 |
| Multiple tumors | 2.020 (1.279–3.191) | 0.003 | 1.815 (1.125–2.927) | 0.015 |
| LVI | 1.866 (1.232–2.826) | 0.003 | ||
| PNI | 1.825 (1.156–2.880) | 0.010 | ||
| LN metastasis | 2.277 (1.424–3.642) | 0.001 | 2.004 (1.221–3.289) | 0.006 |
| Resection margin | 0.988 (0.972–1.044) | 0.144 | ||
| HBV | 1.135 (0.685–1.881) | 0.623 | ||
| HCV | 1.550 (0.624–3.849) | 0.345 | ||
LVI lymphovascular invasion, PNI perineural invasion, HBV hepatitis B virus, HCV hepatitis C virus, PT–INR prothrombin time–international normalized ratio