Table 3.
Predictors of survival after resection of intrahepatic cholangiocarcinoma (n = 153)
| Characteristic | Univariate | Multivariate | ||
|---|---|---|---|---|
| HR (95 % CI) | p value | HR (95 % CI) | p value | |
| Sex | 0.873 (0.568–1.344) | 0.538 | ||
| Age | 1.011 (0.988–1.036) | 0.347 | ||
| PT–INR | 24.618 (3.449–161.735) | 0.001 | ||
| Type of resection | 0.137 | |||
| Wedge resection | 0.450 (0.062–3.258) | 0.429 | ||
| Segmentectomy | 0.949 (0.432–2.087) | 0.897 | ||
| Multiple segmentectomy | 0.655 (0.343–1.252) | 0.201 | ||
| Hemihepatectomy | 1 | |||
| Extended hemihepatectomy | 1.677 (0.969–2.903) | 0.065 | ||
| Tumor subtype | 0.367 (0.207–0.654) | 0.001 | 0.536 (0.297–0.968) | 0.039 |
| Histology | 0.680 (0.314–1.475) | 0.329 | ||
| Tumor size ≥4.0 cm | 3.162 (1.928–5.184) | <0.001 | 2.539 (1.512–4.264) | <0.001 |
| Multiple tumor | 2.475 (1.585–3.864) | <0.001 | 1.782 (1.122–2.828) | 0.014 |
| LVI | 2.299 (1.520–3.475) | <0.001 | 1.684 (1.107–2.564) | 0.015 |
| PNI | 1.869 (1.181–2.957) | 0.008 | ||
| LN metastasis | 3.902 (2.499–6.091) | <0.001 | 3.567 (2.240–5.680) | <0.001 |
| Resection margin | 0.991 (0.974–1.008) | 0.294 | ||
| HBV | 1.165 (0.695–1.955) | 0.562 | ||
| HCV | 1.226 (0.496–3.026) | 0.659 | ||
LVI lymphovascular invasion, PNI perineural invasion, HBV hepatitis B virus, HCV hepatitis C virus, PT–INR prothrombin time–international normalized ratio