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. Author manuscript; available in PMC: 2015 Sep 1.
Published in final edited form as: Nat Rev Mol Cell Biol. 2015 Feb 4;16(3):144–154. doi: 10.1038/nrm3949

Figure 2.

Figure 2

Cell type-specific enhancers are marked by specific epigenomic features and chromatin accessibility. Genomic features of a ~60 kb region of human chromosome 1 centered around the TAL1 gene ENCODE consortium data of DNase-I hypersensitive (DNase HS) regions and ChIP-Seq for the marks H3K4me2, H3K27me3 and H3K27ac in 7 cell lines. Enhancers known to be responsible for TAL1 transcription in endothelial cells (the −3.8 kb and +19 kb enhancers, relative to the TAL1 promoter, in HUVEC cells) and erythroid cells (the +51 kb enhancer in K562 cells) exhibit cell type-specific DNase HS, H3K4me2 and H3K27ac signals. In cell types where TAL1 is not expressed, the promoter and gene body are devoid of DNase HS and histone modifications indicative of enhancer activation (H3K4me2, H3K27ac), and exhibit variable levels of the repressive H3K27me3 mark. Shaded boxes indicate cell-restricted or cell-specific enhancers regions.