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. Author manuscript; available in PMC: 2016 Feb 2.
Published in final edited form as: Medchemcomm. 2015 Feb 2;6:555–563. doi: 10.1039/C4MD00571F

Figure 3.

Figure 3

Protection against hind paw mechanoallodynia in mice resulting from CCI of the sciatic nerve. Triazolyl derivatives were administered at a single dose (p.o.) of 3 μmol/kg at the point of peak pain (7 days post surgery; representative curves of 2-4 determinations). A. Derivatives 5, 6 and 8 – 10, in which the terminal aryl group is a phenyl, substituted phenyl or six-membered heterocycle. B. Derivatives 7, 11, 13, 19 and 20, in which the terminal aryl group is a 3,4-difluorophenyl or five-membered heterocycle. C. Derivatives 16 – 18, with large N6 substitution and in which the terminal aryl group is 5-chlorothien-2-yl. Data are mean ± SEM of n=2 or 4 and analyzed by two-tailed, two-way ANOVA with Bonferroni comparisons to D0 or D7/BL. *P<0.05 vs. D0 and †P<0.05 vs. D7/BL.