Table 4.
Absolute and relative contribution to total valine flux of endogenous Ra of valine (total flux corrected for exogenous supply), valine oxidation, non-oxidative disposal of valine, total valine and body protein balance, fractional synthesis rate of albumin, serum albumin, and blood urea nitrogen
| NP [% flux] | HP [% flux] | P-value difference between mediansa | Median difference between groups (95 % CI)b | |
|---|---|---|---|---|
| (n = 9) | (n = 11) | |||
| Total valine flux (μmol · kg−1 · min−1) | 2.82 (2.48 to 3.37) [100] | 4.26 (3.25 to 5.85) [100] | <0.05 | 1.38 (1.01 to 1.90) |
| Valine dietary intake (μmol · kg−1 · min−1) | 0.91 (0.86 to 0.97) [32.4] | 2.20 (2.01 to 2.30) [52.0] | <0.05 | 1.28 (1.22 to 1.34) |
| Endogenous valine Ra (μmol · kg−1 · min−1) | 1.90 (1.63 to 2.48) [67.7] | 2.06 (1.12 to 3.64) [48.1] | 0.50 | 0.15 (−0.23 to 0.61) |
| Valine oxidation (μmol · kg−1 · min−1) c | 0.68 (0.29 to 1.07) [22.1] | 1.58 (0.38 to 2.93) [35.2] | <0.05 | 0.94 (0.90 to 1.88) |
| NOD of valine (μmol · kg−1 · min−1) c | 2.26 (1.85 to 2.73) [77.9] | 2.73 (0.94 to 3.36) [64.9] | 0.28 | 0.37 (−0.55 to 0.88) |
| Valine balance (μmol · kg−1 · min−1) | 0.24 (−0.20 to 0.63) | 0.54 (−0.73 to 1.75) | 0.57 | 0.29 (−0.67 to 1.17) |
| Protein balance (g · kg−1 · d−1) | 0.78 (−0.65 to 2.00) | 1.73 (−2.35 to 5.59) | 0.57 | 0.94 (−2.15 to 3.74) |
| FSR albumin (% · d−1) | 8.0 (7.1 to 12.0) | 9.3 (6.1 to 13.9) | 0.20 | 1.3 (−0.7 to 3.0) |
| Albumin (g · dL−1) | 3.9 (3.7 to 4.5) | 3.7 (3.4 to 4.2) | 0.13 | −0.2 (−0.4 to 0.1) |
| BUN (mmol · L−1) | 4.0 (2.7 to 5.6) | 7.1 (4.4 to 11.7) | <0.05 | 3.3 (2.2 to 4.9) |
Values are presented as median (range) absolute [and relative] contribution to total valine flux with estimated differences between groups (confidence interval)
NP normal protein (2 g · kg−1 · d−1) diet, HP high protein (5 g · kg−1 · d−1) diet, CI confidence interval, NOD non-oxidative disposal, Ra rate of appearance, FSR fractional synthesis rate, BUN blood urea nitrogen
aMann–Whitney U test; bHodges-Lehmann procedure; cbased on n = 8 and n = 10 in the NP and HP group, respectively (see text)