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. Author manuscript; available in PMC: 2016 Jan 15.
Published in final edited form as: Int J Cancer. 2014 Jun 19;136(2):476–486. doi: 10.1002/ijc.29007

Table I.

Different formats of 5F11-BsAbs (BA).

Name Anti-GD2
scFv		 Linker Anti-CD3
scFv		 Formats
5HL(15)BA 5F11-VH-VL (GGGGS)3 huOKT3-VH-
VL		 graphic file with name nihms-709009-t0004.jpg
5HLDS(15)BA 5F11-VH-VLDS (GGGGS)3 huOKT3-VH- VL graphic file with name nihms-709009-t0005.jpg
5LH(15)BA 5F11-VL-VH (GGGGS)3 huOKT3-VH-
VL		 graphic file with name nihms-709009-t0006.jpg
5LHDS(15)BA 5F11-VL-VHDS (GGGGS)3 huOKT3-VH-
VL		 graphic file with name nihms-709009-t0007.jpg
5HLDS(5)BA 5F11-VH-VLDS (GGGGS)1 huOKT3-VH-
VL		 graphic file with name nihms-709009-t0008.jpg
5LHDS(5)BA 5F11-VL-VHDS (GGGGS)1 huOKT3-VH-
VL		 graphic file with name nihms-709009-t0009.jpg
5HLDS(15)BA
(Y) 		Y-5F11-VH-
VLDS		 (GGGGS)3 huOKT3-VH-
VL		 graphic file with name nihms-709009-t0010.jpg

VH-VL or VL-VH: orientation of VH and VL in 5F11-scFv and hOKT3-scFv. DS: Disulfide bond stabilization, indicated by square brackets. 5HLDS(15)BA(Y) is the same format as 5HLDS(15)BA with one additional affinity maturation mutation P104Y in the CDR region21.