Table 2. Subgroup analysis for new-onset TB and NTM among 144,985 patients with and without RA, Taiwan, 2001–2011*.
| Variable | With RA |
Without RA |
aHR (95% CI)‡ | p value | |||||
|---|---|---|---|---|---|---|---|---|---|
| No. events | No. person-years | Incidence† | No. events | No. person-years | Incidence† | ||||
| New-onset TB | |||||||||
| All patients | 518 | 150,284.0 | 3.4 | 1626 | 119,2456.6 | 1.4 | 2.28 (2.06–2.54) | <0.0001 | |
| Age at entry, y | |||||||||
| 18–44 | 54 | 42,192.3 | 1.3 | 130 | 321,916.2 | 0.4 | 2.54 (1.78–3.63) | <0.0001 | |
| 45–64 | 215 | 78,297.6 | 2.7 | 689 | 627,394.5 | 1.1 | 2.23 (1.90–2.63) | <0.0001 | |
| >65 | 249 | 29,794.0 | 8.4 | 807 | 243,145.9 | 3.3 | 2.28 (1.96–2.65) | <0.0001 | |
| Sex | |||||||||
| F | 307 | 118,858.3 | 2.6 | 909 | 936,265.5 | 1.0 | 2.38 (2.08–2.74) | <0.0001 | |
| M | 211 | 31,425.7 | 6.7 | 717 | 256,191.2 | 2.8 | 2.16 (1.84–2.54) | <0.0001 | |
| Concurrent condition | |||||||||
| CVD | 204 | 41,104.2 | 5.0 | 671 | 270,893.6 | 2.5 | 1.99 (1.69–2.34) | <0.0001 | |
| DM | 58 | 11,952.4 | 4.9 | 261 | 89,868.3 | 2.9 | 1.69 (1.26–2.27) | 0.001 | |
| Hyperlipidemia | 59 | 14,371.2 | 4.1 | 137 | 83,859.8 | 1.6 | 2.49 (1.80–3.43) | <0.0001 | |
| Liver cirrhosis | 45 | 14,122.1 | 3.2 | 123 | 72,188.4 | 1.7 | 1.89 (1.33–2.69) | 0.0001 | |
| COPD | 74 | 11,232.7 | 6.6 | 343 | 77,702.4 | 4.4 | 1.40 (1.08–1.81) | 0.011 | |
| Urbanization | |||||||||
| Urban | 265 | 88,389.5 | 3.0 | 823 | 708,145.9 | 1.2 | 2.39 (2.06–2.77) | <0.0001 | |
| Suburban | 80 | 21,371.3 | 3.7 | 257 | 169,798.3 | 1.5 | 2.16 (1.66–2.82) | <0.0001 | |
| Rural |
173 |
40,523.2 |
4.3 |
|
546 |
314,512.5 |
1.7 |
2.20 (1.84–2.64) |
<0.0001 |
| New-onset NTM | |||||||||
| All patients | 52 | 151,633.4 | 0.3 | 79 | 1,198,369.7 | 0.1 | 6.24 (4.24–9.17) | <0.0001 | |
| Age at entry, y | |||||||||
| 18–44 | 6 | 42,367.8 | 0.1 | 12 | 322,534.9 | 0.0 | 3.70 (1.22–11.24) | <0.05 | |
| 45–64 | 25 | 78,903.7 | 0.3 | 36 | 630,397.4 | 0.1 | 6.89 (3.93–12.07) | <0.0001 | |
| >65 | 21 | 30,361.9 | 0.7 | 31 | 245,437.5 | 0.1 | 6.71 (3.67–12.28) | <0.0001 | |
| Sex | |||||||||
| F | 30 | 119,677.3 | 0.3 | 55 | 939,708.1 | 0.1 | 5.80 (3.55–9.47) | <0.0001 | |
| M | 22 | 31,956.1 | 0.7 | 24 | 258,661.7 | 0.1 | 7.08 (3.77–13.29) | <0.0001 | |
| Concurrent condition | |||||||||
| CVD | 15 | 41,555.1 | 0.4 | 24 | 273,076.0 | 0.1 | 5.03 (2.51–10.07) | <0.0001 | |
| DM | 5 | 12,087.8 | 0.4 | 7 | 90,698.9 | 0.1 | 9.84 (2.79–34.75) | <0.001 | |
| Hyperlipidemia | 4 | 14,523.6 | 0.3 | 6 | 84,326.4 | 0.1 | 6.16 (1.46–26.02) | <0.05 | |
| Liver cirrhosis | 4 | 14,219.5 | 0.3 | 7 | 72,638.1 | 0.1 | 4.77 (1.24–18.38) | <0.05 | |
| COPD | 5 | 11,451.8 | 0.4 | 15 | 78,904.5 | 0.2 | 3.02 (1.04–8.78) | <0.05 | |
| Urbanization | |||||||||
| Urban | 27 | 89,070.6 | 0.3 | 38 | 711,281.4 | 0.1 | 5.91 (3.42–10.21) | <0.0001 | |
| Suburban | 11 | 21,556.7 | 0.5 | 10 | 170,651.8 | 0.1 | 13.85 (5.32–36.03) | <0.0001 | |
| Rural | 14 | 41,006.0 | 0.3 | 31 | 316,436.5 | 0.1 | 4.51 (2.28–8.93) | <0.0001 | |
*aHR, HR, adjusted hazard ratio; COPD, chronic obstructive pulmonary disease; CVD, cardiovascular disease; DM, diabetes mellitus; NTM, nontuberculous mycobacteria; RA, rheumatoid arthritis TB, tuberculosis. †Rate per 1,000 person-years. ‡Adjusted for age, sex, Charlson Comorbidity Index score, and urbanization.