Table. Serologic, immunohistopathologic, and molecular test results for patients with infective endocarditis caused by Bartonella spp. or Coxiella burnetii, Brazil*.
Patient no., by infection type | Serum IgG ≥800 by IFA† | Immunohistochemical analysis of cardiac valve vegetation |
Microorganism by histologic analysis | PCR‡ | Species of Bartonella | |
---|---|---|---|---|---|---|
Bartonella spp. | C. burnetii | |||||
Bartonella spp. | ||||||
1 | + | + | Neg | Gram-negative coccobacilli | + | B. quintana |
2 | + | + | Neg | Gram-negative coccobacilli | + | B. henselae |
3 | + | + | Neg | None | + | B. henselae |
4 | + | NA | NA | NA | Neg | NA |
5 | + | + | Neg | Gram-negative coccobacilli | + | NA |
6 | + | + | Neg | Gram-negative coccobacilli | + | B. quintana |
7 | + | NA | NA | NA | + | B. henselae |
8 | + | NA | NA | NA | + | NA |
9 | + | NA | NA | NA | Neg | NA |
10 | + | + | Neg | Gram-negative cocci | + | B. henselae |
C. burnetii | Serum anti–phase I IgG ≥800 by IFA§ | Immunohistochemical analysis of cardiac valve vegetation |
Microorganism by histologic analysis | PCR‡ | Q fever endocarditis (6) | |
---|---|---|---|---|---|---|
Bartonella spp. | C. burnetii | |||||
11 | + | Neg | + | Small gram-negative coccobacilli | + | Definite 2A criteria |
12 | + | Neg | + | None | + | Definite 2A criteria |
13 | + | Neg | + | None | + | Definite 2A criteria |
14 | + | NA | NA | NA | + | Definite 2B criteria¶ |
*IFA, immunofluorescence assay; +, positive; Neg, negative; NA, material not available for analysis. ¶Serologic result >6,400 and vegetation on ecocardiography. †B. henselae or B. quintana. ‡Serum or tissue sample. §C. burnetii.