Table 3.
Stratified analyses of the association between log2(PIIINP) and vascular measurements by level of C-reactive protein (mg/L), Cardiovascular Health Study, 1996–1997
log2(PIIINP) | ||||
---|---|---|---|---|
N | Estimate | P | P-int* | |
Carotid intima-media thickness (mm) | 0.02 | |||
CRP≤1 | 500 | 0.034 (−0.111, 0.179) | .65 | |
1<CRP≤3 | 723 | 0.045 (−0.077, 0.167) | .47 | |
3<CRP≤10 | 658 | 0.117 (−0.008, 0.242) | .07 | |
CRP>10 | 169 | 0.369 (0.160, 0.579) | .001 | |
Retinal arteriolar equivalent, trunk (µm) | 0.04 | |||
CRP≤1 | 312 | 1.39 (−2.84, 5.62) | .52 | |
1<CRP≤3 | 445 | 2.71 (−0.78, 6.20) | .13 | |
3<CRP≤10 | 405 | −4.54 (−8.28, −0.80) | .02 | |
CRP>10 | 108 | −2.30 (−8.04, 3.44) | .43 | |
Retinal venous equivalent, (µm) | 0.03 | |||
CRP≤1 | 312 | 1.78 (−2.44, 6.00) | .41 | |
1<CRP≤3 | 445 | 1.81 (−1.68, 5.30) | .31 | |
3<CRP≤10 | 405 | −3.46 (−7.20, 0.28) | .07 | |
CRP>10 | 108 | −4.40 (−10.1, 1.34) | .13 |
Eq=equivalent, CRP=C-reactive protein, PIIINP= procollagen type III N-terminal propeptide
P-interaction for PIIINP and CRP
Entries in table are regression coefficients per unit change in log2(PIIINP)
Adjusted for age, sex, race, clinic, body mass index, smoking status, pack years, alcohol consumption, physical activity, systolic blood pressure, total cholesterol, albumin, C-reactive protein, fasting glucose, use of medications for hypertension, diabetes, or hypercholesterolemia.