Figure 10.

Examples of 24 h simulations of CLAD-assisted treatment for refractory status epilepticus in (A) a 40 year old, 50 kg, 150 cm tall female, (B) a 60 year old, 75 kg, 175 cm tall male, (C) a 40 year old, 100 kg, 150 cm tall female, and (D) an 80 year old, 100 kg, 200 cm tall male. In each case the target BSP level (top panel, red dashed line) is increased from zero to 80% over 10 min, held for 8 h, reduced over 10 min to 60%, held for another 8 h, then tapered gradually over 8 h to 0.2. The patient PK dynamics are subject to a continuous stochastic load disturbance (dist., red curve). The robut controller adjusts the infusion rage continuously (cont., blue curve) without exceeding the maximum allowed rate (12 mg kg⁻¹ h⁻¹, red dashed line). The cumulative dose over the preceding hour (cum., shaded blue curve) also stays within the safety limit (red dashed line).