Table 1.
Schnider model for propofol pharmacokinetics (PK). Vi, volume of body compartment i; CLi, drug clearance for compartment i; kij, rate constant for drug transport from compartment i into compartment j. LBM, lean body mass. LBM is calculated according to the James formula as: males: LBM (1.10 × weight(kg)) −128 × (weight2/(100 × height(m))2), females: (1.07 × weight(kg)) −148 × (weight2/(100 × height(m))2).
| Parameter | Value/Equation | CoV | Units |
|---|---|---|---|
| V1 | 4.27 | 4.04 | L |
| V2 | 18.9–0.391 (age-53) | 1 | L |
| V3 | 238 | 14.35 | L |
| CL1 | 1.89 + 0.0456 (mass-77)−0.068 (LBM-59) + 0.0264 (height-177) | 10.05 | L/min |
| CL2 | 1.29–0.024 (age-53) | 1 | L/min |
| CL3 | 0.836 | 11.79 | L/min |
| k10 | CL1/V1 | — | min-1 |
| k12 | CL2/V1 | — | min-1 |
| k21 | CL2/V2 | — | min-1 |
| k13 | CL3/V1 | — | min-1 |
| k31 | CL3/V3 | — | min-1 |
| k14 | 0.456 | — | min-1 |
| k41 | 0.456 | — | min-1 |