Skip to main content
. Author manuscript; available in PMC: 2016 Jul 16.
Published in final edited form as: Mol Cell. 2015 Jul 2;59(2):163–175. doi: 10.1016/j.molcel.2015.05.038

Figure 5. Lack of strand bias of URA3 mutations in the DBY747 pol3-L612M msh2Δ strain at ARS1.

Figure 5

(A) Hot spot mutations in URA3 observed in OR1 in the DBY747 pol3-L612M msh2Δ strain. The URA3 ORF (boxed arrow) is located ~600 bp to the left of ARS1 on chromosome 4 and is not drawn to scale. Strand specific mutation rates for each site were calculated as described in the text, and the leading and lagging strand hot spot mutation rates given on the far right are the sum of all hot spot mutations on that strand. (B) Hot spot mutations in URA3 near ARS1 observed in OR2 in the DBY747 pol3-L612M msh2Δ strain. The orientation of URA3 is reversed from that in (A).

See also Figure S7 and Tables S5 and S6.