Table 5.
Associations between folate intake and risk of preeclampsia by severity of preeclampsia (N=1059), Urban China, 2010–2012
| Folate intake | Controls |
Mild preeclampsia (n = 137) |
Severe preeclampsia (n = 216) |
||
|---|---|---|---|---|---|
| Cases | ORa (95% CI) | Cases | ORa (95% CI) | ||
| Folic acid supplements | |||||
| Nonusers | 150 | 43 | 1 | 72 | 1 |
| Users | 556 | 94 | 0.50 (0.30, 0.81) | 144 | 0.69 (0.46, 1.04) |
| Dietary folate intake (μg/day) | |||||
| Before conception | |||||
| Q1 (<116.0) | 176 | 27 | 1 | 66 | 1 |
| Q2 (116.0, 152.2) | 177 | 31 | 1.19 (0.65, 2.17) | 47 | 0.86 (0.53, 1.40) |
| Q3 (152.2, 229.9) | 177 | 47 | 1.85 (1.05, 3.26) | 64 | 0.98 (0.62, 1.56) |
| Q4 (≥229.9) | 176 | 32 | 1.13 (0.61, 2.07) | 39 | 0.63 (0.39, 1.05) |
| P for trend | 0.38 | 0.15 | |||
| During pregnancy | |||||
| Q1 (<151.6) | 176 | 27 | 1 | 70 | 1 |
| Q2 (151.6, 194.2) | 178 | 32 | 1.30 (0.71, 2.39) | 47 | 0.85 (0.52, 1.38) |
| Q3 (194.2, 274.4) | 176 | 41 | 1.71 (0.95, 3.08) | 60 | 0.98 (0.62, 1.57) |
| Q4 (≥274.4) | 176 | 37 | 1.25 (0.69, 2.27) | 39 | 0.52 (0.31, 0.87) |
| P for trend | 0.36 | 0.037 | |||
Abbreviations: CI, confidence interval; OR, odds ratio.
a
Adjusted for maternal age, education level, maternal diabetes, prepregnancy BMI, weight gain during pregnancy, family monthly income per capita, multiple birth, maternal employment during pregnancy, parity, history of gestational hypertension and dietary folate intake or folic acid supplements.