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. 2015 Jun 12;29(8):1170–1183. doi: 10.1210/me.2015-1080

Figure 5.

Figure 5.

DNA CpG methylation profiles of the miR-137 gene locus in human PC and BC specimens. A, Analysis of DNA methylation within the promoter and gene body of the miR-137 host gene (the microRNA gene locus) in metastatic PC samples compared with normal prostate samples in the GSE38240 dataset, which contains 4 normal (N) and 8 metastatic PC (Met) patient samples assayed with the Illumina Infinium Human Methylation 450K BeadChip kit. Our results include 10 CpG clusters. DNA methylation levels are significantly increased (P < .05) in metastatic PC compared with normal prostate tissue. B, Analysis of DNA methylation within the miR-137 host gene (the microRNA gene locus) in breast tissue samples representing progression of cancer from DCIS to BC and compared with normal breast tissue samples in the GSE60185 dataset, which includes 46 normal breast biopsy samples, 22 samples from patients with DCIS, 31 samples from patients with mixed lesions (containing both DCIS and invasive BC), and 186 samples from patients with invasive BC assayed with the Illumina Infinium Human Methylation 450K BeadChip kit. DNA methylation levels within the miR-137 host gene locus are significantly higher (P < .05) in BC compared with normal breast tissue.