. Author manuscript; available in PMC: 2015 Aug 1.

Published in final edited form as: Curr Opin Pharmacol. 2015 Jun 18;23:82–91. doi: 10.1016/j.coph.2015.05.017

Table 1. Summary of PI3K classes.

	Isoforms	Tissue distribution	Substrate	Product	Adaptor molecules
Class IA	p110α	Ubiquitous	PI(4,5)P₂	PI(3,4,5)P₃ aka PIP₃	p85α(p50α,p55α) p85β; p55γ
	p110β	Ubiquitous
	p110†	Leukocytes, neurons
Class IB	p110γ	Leukocytes, cardiac myocytes	PI(4,5)P₂	PI(3,4,5)P₃	p101/p84/p87
Class II	C2α	Epithelium, endothelium	PI, PI4P	PI3P, PI(3,4)P₂
	C2β	Ubiquitous
	C2γ	Hepatocytes
Class III	VPS34	Ubiquitous	PI	PI3P	VPS15(p150)