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. 2015 Jul 29;35(30):10878–10887. doi: 10.1523/JNEUROSCI.1248-15.2015

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Copyright © 2015 Gant et al.

This article is freely available online through the J Neurosci Author Open Choice option.

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Figure 4. — FKBP1b overexpression reversed the age-related augmentation of the sAHP in hippocampal neurons from the MWM-tested aged animals. A, Representative traces of the sAHP following a burst of four action potentials elicited by an intracellular current pulse (lower trace) in hippocampal neurons of an Aged-Control rat (blue) and an Aged-FKBP1b rat (red). B, sAHP amplitude and duration were substantially greater in neurons from Aged-Control rats than neurons from Young-Control rats (p < 0.0001) or Aged-FKBP1b (p < 0.0001) rats, but did not differ between Aged-FKBP1b and Young-Control rats. Asterisks denote a significant difference from Aged-Control.