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. 2015 Aug;43(8):1226–1235. doi: 10.1124/dmd.115.064428

Fig. 7.

Fig. 7.

CYP2C19 peptides downstream from exon 2 failed to detect residual CYP2C19 wild-type protein in CYP2C19*2 and CYP2C19*35 liver microsomes. (A) The location of the peptide probes used relative to CYP2C19 exons and to rs12769205 and rs4244285. (B) Expression of CYP2C19 protein quantified in pooled human liver microsomes from CYP2C19*1/*1, CYP2C19*2/*2, and CYP2C19*1/*35 livers using exon 2, 4, and 8 specific peptide probes. Results are graphed relative to CYP2C19 protein in CYP2C19*1/*1 pooled liver microsomes (100%). Less than the lower limit of quantitation (<LLOQ).