Fig. 10.

Effect of CM572 across human tumor cell lines from different organ sites and comparison with the effect in normal cell types. CM572 was incubated with SK-N-SH neuroblastoma, MCF-7 breast adenocarcinoma, PANC-1 pancreatic epithelioid carcinoma, normal HEM, and normal HMEC at the indicated concentrations of CM572 for 24 hours (SK-N-SH, PANC-1, HEM) or 48 hours (MCF-7, HMEC). Cell viability was determined after the incubation period using the MTT assay as described in Materials and Methods. Data are the averages of three or four experiments, ± S.D. Each experiment was performed using five wells for each condition.