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. 2015 Aug;88(2):273–280. doi: 10.1124/mol.115.098707

TABLE 1.

Effects of mutations within the two pyrethroid receptor sites on the action of DMT and PMT

Symbols ↓, ↑, and ≈ indicate decrease, increase, or insignificant change of the ligand potency, respectively.

PyR1				PyR2
Mutant	Ref.^a	DMT	PMT	Mutant	Ref.^a	DMT	PMT
L^2k7F/I	1	↓/↓	≈ /↑	I^1k7A	3	↓	↓
M^2k11T	1	↓	↓	V^1k11A	3	↓	↓
				S^1o2A	5	↓	↓
L^2o6I	1	↓	↓	L^1o6I/A	3,5	↑/≈	≈/↑
T^2o10I	1	↓	↓	I^1o10C	3	↓	↓
L^2o13F	1	↓	≈	T^1o13W	3	≈	≈
C^2o14A	1	↓	↑
V²ⁱ¹⁸G	3	↓	↓	L¹ⁱ¹⁸G	3	↓	↓
F²ⁱ²²S^b	5	↓	↓	I¹ⁱ²²A	5	↓	↓
L²ⁱ²⁵A	5	↓	↓	I¹ⁱ²⁵A	5	≈	≈
L²ⁱ²⁶A	5	↓	↓
				S¹ⁱ²⁹A	5	↓	↓
I³ⁱ¹²A	2	↑	↑	V²ⁱ¹²A/L	5	≈/↑	↑/↑
F³ⁱ¹³C	3	↓	↓	I²ⁱ¹³M	3	≈	↓
S³ⁱ¹⁵A	2	≈	≈	N²ⁱ¹⁵S	5	↓	↓
F³ⁱ¹⁶A	2	↓	↓	L²ⁱ¹⁶F/S	3	↓/↓	↓/↓
F³ⁱ¹⁷I	4	↓	↓
N³ⁱ²⁰A	2	↓	↓	N²ⁱ²⁰A	5	≈	≈

^{^a}

References: 1 (Usherwood et al., 2007); 2 (Du et al., 2009); 3 (Du et al., 2013) and references therein; 4 (Tan et al., 2005); and 5, this study (Figs. 3B and 4).

^{^b}

F²ⁱ²² contributes to both PyR1 and PyR2.