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. 2015 Aug;88(2):256–264. doi: 10.1124/mol.115.098285

Fig. 3.

Fig. 3.

Menthol enhances the decay of ACh-evoked currents. Representative inward currents in HEK293 cells expressing α3β4 nAChRs in response to (A) 30 μM ACh and (B) 100 μM, with or without menthol (100 μM) and after 60-second washout (A). The holding potential was –50 mV. (C) Menthol (100 μM) alone evokes no current. (D) A 5-minute treatment with menthol (100 μM) alone does not affect the subsequent current evoked by ACh (30 μM). (E) Summary of the peak current evoked by ACh and amount of current decay following 5-minute pretreatment with either control or menthol (n = 3). D, desensitization.