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Menthol enhances the desensitization of the currents evoked by nicotine. Representative inward currents induced by (A) 1 μM, (B) 3 μM, (C) 10 μM, and (D) 100 μM nicotine in the absence of menthol (left), presence of 100 μM menthol (middle), and 5 minutes after washout of the menthol (right). Time constant (τ) and the extent of desensitization (D) were used to characterize the desensitization.
