TABLE 2.

Histologic scoring of pancreatic tissues

H&E-stained pancreas sections were observed and scored (0–3) to grade the extent of acinar edema, cell vacuolation, inflammation, and acinar cell necrosis. Data are presented as mean ± S.E.M.

Groups/Score	Edema (0–3)	Cell Vacuolation (0–3)	Inflammation (0–3)	Necrosis (0–3)
Control (n = 7)	1 ± 0	0 ± 0	0 ± 0	0 ± 0
Cerulein 24 hours (n = 6)	3 ± 0**	0 ± 0	3 ± 0**	1.6 ± 0.5**
Cerulein 24 hours + TPPU (n = 5)	0.5 ± 0.7††	0 ± 0	0.1 ± 0.3††	0 ± 0††
Arginine 48 hours (n = 6)	3 ± 0**	1 ± 0**	3 ± 0**	1 ± 0**
Arginine 48 hours + TPPU (n = 8)	2.5 ± 0.7*	0 ± 0††	2.5 ± 0.7**	0.8 ± 0.3*

^*P < 0.05; **P < 0.01 indicate significant difference between control mice without versus mice with administration of cerulein (24 hours after the initial cerulein injection) and arginine (48 hours after the initial arginine injection).

^†P < 0.05; ^††P < 0.01 indicate significant difference between TPPU-treated (postinduction of AP with cerulein and arginine) versus non-TPPU–treated mice.